diff --git a/library/ui-strings/src/main/res/values/strings.xml b/library/ui-strings/src/main/res/values/strings.xml
index 1a1546459e..3d1a36d4c3 100644
--- a/library/ui-strings/src/main/res/values/strings.xml
+++ b/library/ui-strings/src/main/res/values/strings.xml
@@ -1470,6 +1470,9 @@
     <string name="reason_colon">Reason: %1$s</string>
 
     <string name="avatar">Avatar</string>
+    <string name="avatar_of_space">Avatar of space %1$s</string>
+    <string name="avatar_of_room">Avatar of room %1$s</string>
+    <string name="avatar_of_user">Profile picture of user %1$s</string>
 
     <!-- Consent modal -->
     <string name="dialog_user_consent_content">To continue using the %1$s homeserver you must review and agree to the terms and conditions.</string>
diff --git a/vector/src/main/java/im/vector/app/features/home/AvatarRenderer.kt b/vector/src/main/java/im/vector/app/features/home/AvatarRenderer.kt
index f4ffbb826a..7214db41ef 100644
--- a/vector/src/main/java/im/vector/app/features/home/AvatarRenderer.kt
+++ b/vector/src/main/java/im/vector/app/features/home/AvatarRenderer.kt
@@ -35,13 +35,16 @@ import com.bumptech.glide.request.RequestOptions
 import com.bumptech.glide.request.target.DrawableImageViewTarget
 import com.bumptech.glide.request.target.Target
 import com.bumptech.glide.signature.ObjectKey
+import im.vector.app.R
 import im.vector.app.core.contacts.MappedContact
 import im.vector.app.core.di.ActiveSessionHolder
 import im.vector.app.core.glide.AvatarPlaceholder
 import im.vector.app.core.glide.GlideApp
 import im.vector.app.core.glide.GlideRequest
 import im.vector.app.core.glide.GlideRequests
+import im.vector.app.core.resources.StringProvider
 import im.vector.app.core.utils.DimensionConverter
+import im.vector.app.features.displayname.getBestName
 import im.vector.app.features.home.room.detail.timeline.helper.MatrixItemColorProvider
 import jp.wasabeef.glide.transformations.BlurTransformation
 import jp.wasabeef.glide.transformations.ColorFilterTransformation
@@ -58,7 +61,8 @@ import javax.inject.Inject
 class AvatarRenderer @Inject constructor(
         private val activeSessionHolder: ActiveSessionHolder,
         private val matrixItemColorProvider: MatrixItemColorProvider,
-        private val dimensionConverter: DimensionConverter
+        private val dimensionConverter: DimensionConverter,
+        private val stringProvider: StringProvider,
 ) {
 
     companion object {
@@ -67,6 +71,7 @@ class AvatarRenderer @Inject constructor(
 
     @UiThread
     fun render(matrixItem: MatrixItem, imageView: ImageView) {
+        imageView.setContentDescription(matrixItem)
         render(
                 GlideApp.with(imageView),
                 matrixItem,
@@ -100,6 +105,7 @@ class AvatarRenderer @Inject constructor(
 
     @UiThread
     fun render(matrixItem: MatrixItem, imageView: ImageView, glideRequests: GlideRequests) {
+        imageView.setContentDescription(matrixItem)
         render(
                 glideRequests,
                 matrixItem,
@@ -109,6 +115,7 @@ class AvatarRenderer @Inject constructor(
 
     @UiThread
     fun render(matrixItem: MatrixItem, localUri: Uri?, imageView: ImageView) {
+        imageView.setContentDescription(matrixItem)
         val placeholder = getPlaceholderDrawable(matrixItem)
         GlideApp.with(imageView)
                 .load(localUri?.let { File(localUri.path!!) })
@@ -295,4 +302,28 @@ class AvatarRenderer @Inject constructor(
         return activeSessionHolder.getSafeActiveSession()?.contentUrlResolver()
                 ?.resolveThumbnail(avatarUrl, THUMBNAIL_SIZE, THUMBNAIL_SIZE, ContentUrlResolver.ThumbnailMethod.SCALE)
     }
+
+    /**
+     * Accessibility management.
+     */
+    private fun ImageView.setContentDescription(matrixItem: MatrixItem) {
+        // Do not set contentDescription if the ImageView should be ignored regarding accessibility.
+        if (isImportantForAccessibility.not()) return
+        when (matrixItem) {
+            is MatrixItem.SpaceItem -> {
+                contentDescription = stringProvider.getString(R.string.avatar_of_space, matrixItem.getBestName())
+            }
+            is MatrixItem.RoomAliasItem,
+            is MatrixItem.RoomItem -> {
+                contentDescription = stringProvider.getString(R.string.avatar_of_room, matrixItem.getBestName())
+            }
+            is MatrixItem.UserItem -> {
+                contentDescription = stringProvider.getString(R.string.avatar_of_user, matrixItem.getBestName())
+            }
+            is MatrixItem.EveryoneInRoomItem,
+            is MatrixItem.EventItem -> {
+                // NA
+            }
+        }
+    }
 }